Cystatin C level as a marker of renal function in allogeneic hematopoietic stem cell transplantation

• Published in: International journal of hematology Vol. 91; no. 3; pp. 471 - 477
• Main Authors: Muto, Hideharu, Ohashi, Kazuteru, Ando, Minoru, Akiyama, Hideki, Sakamaki, Hisashi
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01-04-2010; Springer; Springer Nature B.V
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - diagnosis; Acute Kidney Injury - epidemiology; Adolescent; Adult; Biological and medical sciences; Biomarkers - blood; Cystatin C - blood; Female; Glomerular Filtration Rate; Hematologic and hematopoietic diseases; Hematology; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic Stem Cell Transplantation - statistics & numerical data; Humans; Incidence; Kidney - physiology; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Multivariate Analysis; Oncology; Original Article; Predictive Value of Tests; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - epidemiology; Retrospective Studies; Risk Factors; Transplantation, Homologous; Young Adult; Hematopoietic stem cell transplantation; Renal function; Cystatin C; Allogeneic hematopoietic stem cell transplantation; Hematology; Stem cell; Hematopoietic cell; Homograft; Biological marker
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-010-0521-0

We retrospectively reviewed the medical records of 75 allogeneic hematopoietic transplant recipients and evaluated cystatin C as a potential marker of subsequent renal dysfunction. Acute kidney injury developed in 31 of 75 patients after a median of 46 days post-transplantation (range 1–502 days), while worsening of chronic kidney disease (CKD) was observed in 21 patients during the observational period. Cystatin C level was significantly elevated after allogeneic transplantation (
P
 < 0.001). Multivariate analysis revealed the use of calcineurin inhibitors as a major cause of cystatin C elevation (odds ratio 7.26,
P
 = 0.04). A strong inverse correlation was also noted between cystatin C and estimated glomerular filtration rate (
r
 = −0.682,
P
 < 0.001). Cystatin C measurement could provide a useful clinical tool to identify hematopoietic stem cell transplantation recipients at an increased risk for CKD.