Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolemia

• Published in: The American journal of clinical nutrition Vol. 67; no. 3; pp. 367 - 376
• Main Authors: Davidson, MH, Maki, KC, Kong, JC, Dugan, LD, Torri, SA, Hall, HA, Drennan, KB, Anderson, SM, Fulgoni, VL, Saldanha, LG, Olson, BH
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01-03-1998; American Society for Clinical Nutrition; American Society for Clinical Nutrition, Inc
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; BLOOD LIPIDS; BLOOD SERUM; CHOLESTEROL; Cholesterol, HDL - blood; Cholesterol, LDL - blood; DIET; Diet Records; DIET TREATMENT; Dietary fiber; Dietary Fiber - administration & dosage; Dietary Fiber - adverse effects; Dietary Fiber - therapeutic use; DIETARY FIBRES; Disorders of blood lipids. Hyperlipoproteinemia; DOSAGE EFFECTS; Double-Blind Method; ENERGY INTAKE; EXPERIMENTATION; Female; HIGH DENSITY LIPOPROTEIN; HUMAN NUTRITION; Humans; Hypercholesterolemia - blood; Hypercholesterolemia - diet therapy; HYPERLIPIDAEMIA; Lipids; LIPOPROTEINS; LONGITUDINAL STUDIES; LOW DENSITY LIPOPROTEIN; Male; Medical sciences; MEN; Metabolic diseases; Middle Aged; MUCILAGES; NATIONAL CHOLESTEROL EDUCATION PROGRAM; NUTRIENT INTAKE; Nutrition; PATIENT COMPLIANCE; Psyllium - administration & dosage; Psyllium - adverse effects; Psyllium - therapeutic use; SEEDS; SUPPLEMENTS; TRIGLYCERIDES; Triglycerides - blood; WOMEN; Human; Hypercholesterolemia; Treatment; Diet; Metabolic diseases; Cholesterol LDL; Dyslipemia; Dietary fiber; Feeding
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/67.3.367

The effects of consuming foods containing 0 (control), 3.4, 6.8, or 10.2 g psyllium seed husk (PSH)/d for 24 wk on the serum lipid profile were assessed in this randomized, double-blind controlled study. Men and women (n = 286) with LDL-cholesterol concentrations between 3.36 and 5.68 mmol/L (130 and 220 mg/dL) were randomly assigned to one of four treatment groups after following a low-fat diet for > or = 8 wk. At week 24, LDL cholesterol was 3% above baseline in the control group. In the group consuming 10.2 g PSH/d, LDL cholesterol remained below baseline during treatment, with a value 5.3% below that of the control group at week 24 (P < 0.05 compared with the control group). No significant differences were observed in HDL cholesterol or triacylglycerol. Although modest, the effect of 10.2 g PSH/d on LDL cholesterol (relative to the control) persisted throughout the 24-wk treatment period, indicating potential for long-term benefit.