p53 mRNA Metabolism Links with the DNA Damage Response

• Published in: Genes Vol. 12; no. 9; p. 1446
• Main Authors: Vadivel Gnanasundram, Sivakumar, Bonczek, Ondrej, Wang, Lixiao, Chen, Sa, Fahraeus, Robin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20-09-2021; MDPI
• Subjects: Animals; Apoptosis; ATM kinase; Cancer; Cell cycle; Cell division; Cyclin-dependent kinases; Deoxyribonucleic acid; DNA; DNA Damage; DNA damage response; DNA repair; DNA Repair - physiology; Genes; Genomes; Genotoxicity; Humans; Kinases; MDM2; Medical prognosis; mRNA; MRNA translation; Mutation; P53; p53 Protein; Phosphorylation; Proteins; Regulation; Review; RNA metabolism; RNA, Messenger - metabolism; RNA-binding protein; RNA-binding proteins; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Roles; Senescence; Sensors; Tumor suppressor genes; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Untranslated Regions; mRNA translation; ATM kinase; DNA damage response; MDM2; RNA-binding proteins; RNA metabolism; p53
• ISSN: 2073-4425; 2073-4425
• DOI: 10.3390/genes12091446

Human cells are subjected to continuous challenges by different genotoxic stress attacks. DNA damage leads to erroneous mutations, which can alter the function of oncogenes or tumor suppressors, resulting in cancer development. To circumvent this, cells activate the DNA damage response (DDR), which mainly involves cell cycle regulation and DNA repair processes. The tumor suppressor p53 plays a pivotal role in the DDR by halting the cell cycle and facilitating the DNA repair processes. Various pathways and factors participating in the detection and repair of DNA have been described, including scores of RNA-binding proteins (RBPs) and RNAs. It has become increasingly clear that p53's role is multitasking, and p53 mRNA regulation plays a prominent part in the DDR. This review is aimed at covering the p53 RNA metabolism linked to the DDR and highlights the recent findings.