Primary Splenic Peripheral Nerve Sheath Tumour in a Dog

• Published in: Journal of comparative pathology Vol. 141; no. 2; pp. 195 - 198
• Main Authors: Bergmann, W., Burgener, I.A., Roccabianca, P., Rytz, U., Welle, M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-08-2009
• Subjects: Animals; Biomarkers, Tumor - analysis; dog; Dog Diseases - pathology; Dogs; Euthanasia, Animal; Fatal Outcome; Female; Glial Fibrillary Acidic Protein - analysis; histopathology; immunohistochemistry; Immunohistochemistry - veterinary; myelin sheath; neoplasms; Nerve Sheath Neoplasms - chemistry; Nerve Sheath Neoplasms - pathology; Nerve Sheath Neoplasms - surgery; Nerve Sheath Neoplasms - veterinary; peripheral nerve sheath tumor; peripheral nerve sheath tumour; peripheral nerves; S100 Proteins - analysis; spleen; Splenic Neoplasms - chemistry; Splenic Neoplasms - pathology; Splenic Neoplasms - surgery; Splenic Neoplasms - veterinary; Vimentin - analysis; peripheral nerve sheath tumour; spleen; dog
• ISSN: 0021-9975; 1532-3129
• DOI: 10.1016/j.jcpa.2009.03.009

An 8-year-old crossbred dog was presented with a one-month history of progressive weakness, respiratory impairment and abdominal distension. Surgical exploration revealed the presence of a splenic mass that infiltrated the mesentery and was adherent to the stomach and pancreas. The mass was composed of highly cellular areas of spindle-shaped cells arranged in interlacing bundles, streams, whorls and storiform patterns (Antoni A pattern) and less cellular areas with more loosely arranged spindle to oval cells (Antoni B pattern). The majority of neoplastic cells expressed vimentin, S-100 and glial fibrillary acidic protein (GFAP), but did not express desmin, α-smooth muscle actin or factor VIII. These morphological and immunohistochemical findings characterized the lesion as a malignant peripheral nerve sheath tumour (PNST). Primary splenic PNST has not been documented previously in the dog.