Electrical behavior of T-Wave polarity alternans in patients with congenital long QT syndrome

• Published in: Journal of the American College of Cardiology Vol. 36; no. 1; pp. 167 - 173
• Main Authors: Cruz Filho, Fernando E.S, Maia, Ivan G, Fagundes, Márcio L.A, Barbosa, Rosa Celia P, Alves, Paulo A.G, Sá, Roberto M.S, Boghossian, Silvia H, Ribeiro, Jose Carlos
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-07-2000; Elsevier Science
• Subjects: Action Potentials; Adolescent; Biological and medical sciences; Child; Child, Preschool; Circadian Rhythm - physiology; Electrocardiography, Ambulatory; Electrocardiography. Vectocardiography; Electrodiagnosis. Electric activity recording; Female; Heart Rate - physiology; Humans; Investigative techniques, diagnostic techniques (general aspects); Long QT Syndrome - complications; Long QT Syndrome - congenital; Long QT Syndrome - physiopathology; Male; Medical sciences; Prognosis; Tachycardia, Ventricular - etiology; Tachycardia, Ventricular - physiopathology; Tropical medicine; Lnc; QTcVr; TWPA; CLQTS; MCL; ECG; EpD; CL; QTcI; TWA; Human; Alternance; Arrhythmia; Congenital; Pathophysiology; Variability; Prolonged QT interval; Electrophysiology; Cardiovascular disease; Exploration; Congenital disease; Conduction disorder; Incidence; Electrodiagnosis; Concomitant disease; Cardiac cycle; T wave; Heart block; Heart disease; Electrocardiography; Polarity
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/S0735-1097(00)00694-X

OBJECTIVES
This study was designed to evaluate the incidence and characteristics of onset of T-wave polarity alternans (TWPA) in patients with long QT syndrome.
BACKGROUND
The T-wave alternans is a phenomenon that consists of beat-to-beat variability in the amplitude, morphology, and sometimes polarity of the T-wave, and it may trigger life-threatening arrhythmias.
METHODS
The 24-h Holter recordings of 11 patients with congenital long QT syndrome were studied. Episodes of TWPA with 10 or more consecutive cycles were selected and analyzed as follows: 1) mean cycle length (MCL) and QTc interval duration (QTcI) of the episodes of TWPA and the 10 cycles preceding and succeeding the TWPA; 2) MCL and QTcI of the third, second, and first minute before onset (Mn−3, Mn−2, Mn−1); 3) MCL and QTcI from the tenth to the first cycle immediately preceding the onset of TWPA (R−10 to R−1); 4) MCL and QTcI from the first to the fourteenth cycle during alternans (R0 to R14); 5) MCL and QTcI from the first to the tenth cycle immediately succeeding TWPA (R+1 to R+10); 6) linear correlation (Lnc) between QT interval and cycle length (CL) (LncQT/CL) during alternans and for the 10 preceding cycles; 7) Lnc between the first three alternans cycles and episode duration (Lnc 3CL/EpD); and 8) difference between the longest and shortest QTc interval. We also selected episodes consisting of four or more consecutive cycles in order to analyze daily rhythms of the phenomenon.
RESULTS
The TWPA was observed in 5 (45%) out of the 11 patients studied. The alternans process is initiated by a sudden shortening of the first alternans cycle without previous heart rate changes and ends at the moment when prolongation of the cycle tends to occur. LncQT/CL–alternans: r = 0.38 ± 0.2 (p = 0.20); without alternans: r = 0.81 ± 0.06 (p = 0.01). Lnc 3CL/EpD: r = 0.002 (p = 0.992). The QTc difference during alternans: 312.0 ± 52.1 ms; without alternans: 86.0 ± 36.4 ms (p = 0.001). Daily rhythm: 71% of the episodes occurred between 8 am and 8 pm, with higher incidence during the morning.
CONCLUSIONS
The TWPA was dependent on the cardiac CL; there was loss of the LncQT/CL and an increase in the QT interval variability. Like other biological variables, T-wave polarity alternans has a higher density during the morning.