Neoadjuvant chemoradiotherapy for esophageal cancer:Impact on extracapsular lymph node involvement
AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal cancer.METHODS:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy betw...
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| Published in: | World journal of gastroenterology : WJG Vol. 16; no. 16; pp. 1986 - 1992 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital of Cologne, 50937 Cologne, Germany%Department of Pathology, University of Cologne,50937 Cologne, Germany%Department of Radiation Oncology, University of Cologne, 50937 Cologne, Germany%Department of Pathology, University of Düsseldorf, 40225 Düsseldorf, Germany
28-04-2010
The WJG Press and Baishideng |
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| Online Access: | Get full text |
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| Summary: | AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal cancer.METHODS:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy between 1997 and 2006.One hundred and ninety patients(63.8%) were treated with neoadjuvant CRT prior to resection.A total of 986 metastatic LNs were examined.Survival of the patients was analyzed according to intra-a... |
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| Bibliography: | Adenocarcinoma Lymph node metastasis Neoadjuvant therapy Chemotherapy Squamous cell carcinoma Prognosis Extracapsular lymph node involvement 14-1219/R R735.1 Esophageal cancer; Neoadjuvant therapy; Chemotherapy; Radiotherapy; Adenocarcinoma; Squamous cell carcinoma; Lymph node metastasis; Extracapsular lymph node involvement; Prognosis Radiotherapy Esophageal cancer ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Telephone: +49-221-4784803 Fax: +49-221-4786258 Author contributions: Metzger R was involved in the majority of writing and editing of the manuscript, and coordinating the study; Bollschweiler E performed the statistical analysis and contributed to the conception and design of the manuscript; Drebber U and Baldus SE were responsible for pathological assessment of the resected tumor samples and lymph nodes; Mönig SP and Schröder W contributed to the acquisition of surgical and routine histopathological data; Alakus H was involved in the acquisition of the surgical data and in editing the manuscript; Kocher M performed the neoadjuvant chemoradiotherapy; Hölscher AH coordinated and performed the study and edited the manuscript. Correspondence to: Ralf Metzger, MD, Department of General, Visceral and Cancer Surgery, Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. ralf.metzger@uk-koeln.de |
| ISSN: | 1007-9327 2219-2840 |
| DOI: | 10.3748/wjg.v16.i16.1986 |