Advances in Organocatalytic 1,6‐Addition Reactions: Enantioselective Construction of Remote Stereogenic Centers

Advances in Organocatalytic 1,6‐Addition Reactions: Enantioselective Construction of Remote Stereogenic Centers

Due to the competing 1,4‐addition reactions and the distance from the chirality information, the construction of a remote stereogenic center via 1,6‐addition reactions is often regarded as a great challenge in asymmetric synthesis. Recently, the use of organocatalysts has provided new, excellent alt...

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Bibliographic Details
Published in:Advanced synthesis & catalysis Vol. 359; no. 6; pp. 888 - 912
Main Authors: Chauhan, Pankaj, Kaya, Uğur, Enders, Dieter
Format: Journal Article
Language:English
Published: Heidelberg Wiley Subscription Services, Inc 20-03-2017
Subjects:
1,6-addition reactions
Activation
asymmetric synthesis
Asymmetry
Catalysis
Chemical synthesis
Chirality
Michael addition
organocatalysis
Substrates
Synthesis (chemistry)
vinylogous reactivity
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Summary:Due to the competing 1,4‐addition reactions and the distance from the chirality information, the construction of a remote stereogenic center via 1,6‐addition reactions is often regarded as a great challenge in asymmetric synthesis. Recently, the use of organocatalysts has provided new, excellent alternatives to activate the remote δ‐position and facilitate the enantioselective 1,6‐addition reactions. In this regard, different new activation modes have been devised and new types of substrates have been employed. This review describes all the recent developments in this area.
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ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201601342