NOS1AP Gene Variants and Their Role in Metabolic Syndrome: A Study of Patients with Schizophrenia

• Published in: Biomedicines Vol. 12; no. 3; p. 627
• Main Authors: Mednova, Irina A, Pozhidaev, Ivan V, Tiguntsev, Vladimir V, Bocharova, Anna V, Paderina, Diana Z, Boiko, Anastasiia S, Fedorenko, Olga Y, Kornetova, Elena G, Bokhan, Nikolay A, Stepanov, Vadim A, Ivanova, Svetlana A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12-03-2024; MDPI
• Subjects: Antipsychotics; Association analysis; Calcium (intracellular); Cardiovascular disease; Diabetes; Ethnicity; Females; gene; Genes; Glucose; Hospitals; Insulin resistance; Insulin secretion; Mental disorders; Mental institutions; Metabolic disorders; Metabolic syndrome; Nitric oxide; Nitric-oxide synthase; NOS1AP; Obesity; Oxidation; Pathogenesis; polymorphism; Post traumatic stress disorder; Potassium; Psychotropic drugs; Quality of life; Schizophrenia; Signal transduction; Single-nucleotide polymorphism; Statistical analysis; metabolic syndrome; gene; NOS1AP; antipsychotic; polymorphism; nitric oxide synthase; schizophrenia; pharmacogenetics
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines12030627

Metabolic syndrome (MetS) is common among schizophrenia patients, and one of MetS's causes may be an imbalance in nitric oxide regulation. In this study, we examined associations of three polymorphic variants of the nitric oxide synthase 1 adapter protein (
) gene with MetS in schizophrenia. NOS1AP regulates neuronal nitric oxide synthase, which controls intracellular calcium levels and may influence insulin secretion. The aim of the investigation was to study polymorphic variants of the
gene as possible markers of MetS in patients with schizophrenia. A total of 489 Caucasian patients with schizophrenia (ICD-10) from Siberia (Russia) were included in the study, and 131 (26.8%) patients had MetS (IDF classification, 2007). The participants were genotyped for three single-nucleotide polymorphisms in
(rs12143842, rs10494366, and rs12029454). Logistic regression was used for association analysis. Single-nucleotide polymorphisms, sex, and age served as covariates; the dependent variable was the coded parameter of the presence/absence of MetS. Polymorphisms rs12143842 and rs10494366 showed a stable association even after Bonferroni's correction for multiple comparisons (
= 0.005 and 0.002, respectively), indicating a statistically significant contribution of these polymorphic variants to the pathogenesis of MetS. Our results suggest that in patients with schizophrenia,
may be involved in MetS pathophysiology.