ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 75; no. 9; pp. 1801 - 1803
• Main Authors: Kuo, Chia-Ling, Pilling, Luke C, Atkins, Janice L, Masoli, Jane A H, Delgado, João, Kuchel, George A, Melzer, David
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 16-09-2020
• Subjects: Apolipoprotein E4; Apolipoproteins E - genetics; Betacoronavirus; Biobanks; Biological Specimen Banks; Coronavirus Infections; COVID-19; Genotype; Genotype & phenotype; Genotypes; Humans; Mortality; Pandemics; Pneumonia, Viral; SARS-CoV-2; THE JOURNAL OF GERONTOLOGY: Medical Sciences; United Kingdom; United Kingdom; United Kingdom > UK
• ISSN: 1079-5006; 1758-535X
• DOI: 10.1093/gerona/glaa169

The ApoE e4e4 genotype was associated with COVID-19 test positivity (odds ratio [OR] = 2.31,95% CI: 1.65-3.24, p = 1.19 · 10"6) (1) in the UK Biobank (UKB) cohort, during the epidemic peak in England, from March 16 to April 26,2020. With more COVID-19 test results (March 16 to May 31,2020) and mortality data (to March 31,2020, with incomplete data for April 2020) linked to UKB, the ApoE e4 allele association with COVID-19 test positivity were reevaluated, and with all-cause mortality following test-confirmed COVID-19. Here, Kuo et al investigates the relation between the ApoE e4e4 genotype and mortality with COVID-19 in UK Biobank.