Association of MMP1 , MMP3 , MMP9 , and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population

• Published in: Journal of neuroimmunology Vol. 214; no. 1; pp. 113 - 117
• Main Authors: Mirowska-Guzel, Dagmara, Gromadzka, Grazyna, Czlonkowski, Andrzej, Czlonkowska, Anna
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 29-09-2009
• Subjects: Adult; Allergy and Immunology; Disease susceptibility; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Matrix Metalloproteinase 1 - genetics; Matrix Metalloproteinase 12 - genetics; Matrix Metalloproteinase 3 - genetics; Matrix Metalloproteinase 9 - genetics; Middle Aged; MMPs polymorphisms; Multiple sclerosis; Multiple Sclerosis - enzymology; Multiple Sclerosis - epidemiology; Multiple Sclerosis - genetics; Neurology; PCR; Poland - epidemiology; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Sex Factors; Poland; Multiple sclerosis; Disease susceptibility; MMPs polymorphisms; PCR
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2009.06.014

Abstract Single nucleotide polymorphisms in human MMP genes, including MMP1 (− 1637 1G > 2G), MMP3 (− 1612 5A > 6A), MMP9 (− 1562 C > T), and MMP12 (− 82 A > G), and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated. Increased risk of MS was found among carriers of at least one T allele of MMP9 − 1562 C > T (OR, 1.7; p = 0.0030) and one G allele of MMP12 − 82 A > G (OR, 3.9; p < 0.00001). Additionally, an association between MMP9 genotype and MMP-9 levels in peripheral blood was detected. Our results suggest that MMP9 − 1562 C > T and MMP12 − 82 A > G polymorphisms affect susceptibility to multiple sclerosis.