Effects of medicinal plant extracts from Chinese herbal medicines on the mutagenic activity of benzo[a]pyrene

• Published in: Mutation research Vol. 206; no. 3; p. 327
• Main Authors: Sakai, Y, Nagase, H, Ose, Y, Sato, T, Kawai, M, Mizuno, M
• Format: Journal Article
• Language: English
• Published: Netherlands 01-11-1988
• Subjects: Benzo(a)pyrene - antagonists & inhibitors; Drugs, Chinese Herbal - pharmacology; In Vitro Techniques; Mutagenicity Tests; Mutation - drug effects; Salmonella typhimurium - drug effects
• ISSN: 0027-5107
• DOI: 10.1016/0165-1218(88)90118-8

The effects of medicinal plants on the mutagenicity of benzo[a]pyrene were studied with Salmonella typhimurium tester strains. The chosen medicinal plants are very frequently used as Chinese herbal medicines. Each medicinal plant was extracted with hot water, which is similar to the method used in Chinese medicinal treatment. Cinnamomi cortex, Rhei rhizoma, Scutellariae radix and Rehmanniae radix were found to decrease the mutagenic activity of benzo[a]pyrene. Atractylodis rhizoma also reduced the mutagenicity of benzo[a]pyrene, but this was not certain, because it showed a killing effect on the cell survival test. Bupleuri radix and Aurantii nobilis pericarpium had an enhancing effect, but then neither of these extracts is itself mutagenic. Each medicinal plant extract showed a different effect on the mutagenicity of benzo[a]pyrene. These effects were classified into 5 types: (I) decreasing effect, (II) killing effect, (III) enhancing effect, (IV) enhancing and decreasing effect and (V) inactive.