Malignant peripheral nerve sheath tumor arising spontaneously from retroperitoneal ganglioneuroma: a case report, review of the literature, and immunohistochemical study

• Published in: Human pathology Vol. 23; no. 1; p. 72
• Main Authors: Ghali, V S, Gold, J E, Vincent, R A, Cosgrove, J M
• Format: Journal Article
• Language: English
• Published: United States 01-01-1992
• Subjects: Adult; Cell Transformation, Neoplastic; Ganglioneuroma - pathology; Humans; Immunoenzyme Techniques; Male; Neoplasm Recurrence, Local - pathology; Peripheral Nervous System Neoplasms - pathology; Retroperitoneal Neoplasms - pathology
• ISSN: 0046-8177
• DOI: 10.1016/0046-8177(92)90015-U

We report a case of a malignant peripheral nerve sheath tumor arising from a retroperitoneal ganglioneuroma in an adult male. There was no known previous history of a childhood neuroblastoma or of radiation therapy. In addition, the patient had no stigmata or family history of von Recklinghausen's neurofibromatosis. This case provides evidence that, although rare, spontaneous malignant transformation of ganglioneuroma can occur. Immunohistochemical studies supported that the spindle cell component was of nerve sheath origin.