Comparison of selectivity of LDL removal by double filtration and dextran-sulfate cellulose column plasmapheresis

• Published in: Atherosclerosis Vol. 60; no. 1; p. 23
• Main Authors: Homma, Y, Mikami, Y, Tamachi, H, Nakaya, N, Nakamura, H, Araki, G, Goto, Y
• Format: Journal Article
• Language: English
• Published: Ireland 01-04-1986
• Subjects: Adult; Apolipoprotein A-I; Apolipoprotein A-II; Apolipoproteins A - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Chromatography, Affinity; Dextran Sulfate; Dextrans; Female; Filtration; Humans; Hyperlipoproteinemia Type II - blood; Hyperlipoproteinemia Type II - therapy; Lipoproteins, LDL - blood; Lipoproteins, LDL - isolation & purification; Male; Middle Aged; Plasmapheresis
• ISSN: 0021-9150
• DOI: 10.1016/0021-9150(86)90083-3

The possibility of selective removal of VLDL, IDL and LDL by double filtration (DF) and dextran-sulfate cellulose (DSC) column plasmapheresis was investigated in hypercholesterolemia. Two and a half liters of plasma were treated. Sixty six percent of TC and 68% of LDL-C were removed by DF plasmapheresis. The removal rate of HDL-C was 50% which was significantly lower than that of LDL-C. The removal rate of apoprotein A-I and A-II was also significantly lower than that of apoprotein B. Sixty percent of LDL-C and 61% of apoprotein B were removed by DSC column plasmapheresis while the decrease of HDL-C, apoprotein A-I and A-II was minimal. Therefore, DSC column plasmapheresis could remove atherogenic lipoproteins more selectively than DF plasmapheresis.