Interference with Fluorimetric Assay of Catecholamine by Labetalol

Influence of labetalol and 5-(1-hydroxy-2-aminoethyl) salieylamide (SA), a part of the chemical structure of labetalol, on the fluorimetric assay of catecholamine (CA) was studied. Both labetalol and SA have a weak but significant fluorescence which is indistinguishable from that of CA with peaks of...

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Bibliographic Details
Published in:	The Tohoku Journal of Experimental Medicine Vol. 126; no. 2; pp. 201 - 202
Main Authors:	KOBAYASHI, KIYOSHI, MIURA, YUKIO, TOMIOKA, HIROSHI, SAKUMA, HISAICHI, ADACHI, MAKI, ABE, KEISHI, YOSHINAGA, KAORU
Format:	Journal Article
Language:	English
Published:	Japan Tohoku University Medical Press 01-01-1978
Subjects:	catecholamine Drug Interactions Epinephrine - analysis Ethanolamines - analysis flurimetry labetalol Labetalol - analysis Norepinephrine - analysis Spectrometry, Fluorescence
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Summary:	Influence of labetalol and 5-(1-hydroxy-2-aminoethyl) salieylamide (SA), a part of the chemical structure of labetalol, on the fluorimetric assay of catecholamine (CA) was studied. Both labetalol and SA have a weak but significant fluorescence which is indistinguishable from that of CA with peaks of excitation/emission wavelengths at 410/490. It is thus concluded that an apparent increase in urinary CA observed in patients receiving labetalol is caused by the contamination of labetalol and/or its metabolite, and that the evaluation of urinary CA in hypertensive patients must be done prior to the use of labetalol to avoid any confusion in diagnosis of pheo-chromoeytoma.
ISSN:	0040-8727 1349-3329
DOI:	10.1620/tjem.126.201