Apexification of immature teeth with calcium hydroxide or mineral trioxide aggregate: systematic review and meta-analysis

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 112; no. 4; pp. e36 - e42
• Main Authors: Chala, Sanaa, Abouqal, Redouane, Rida, Sana
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01-10-2011
• Subjects: Apexification - methods; Calcium hydroxide; Calcium Hydroxide - therapeutic use; Clinical trials; Data processing; Dentin, Secondary - drug effects; Dentistry; Glutamates - therapeutic use; Guanine - analogs & derivatives; Guanine - therapeutic use; Humans; IE2 protein; Minerals; Pemetrexed; Reviews; Risk assessment; Root Canal Filling Materials - therapeutic use; Surgery; Teeth; Tooth Apex - drug effects; Tooth Root - growth & development; Treatment Outcome
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1016/j.tripleo.2011.03.047

Objective The aim of this study was to conduct a quantitative systematic review, including published data, comparing the efficacy of mineral trioxide aggregate and calcium hydroxide as material used for the endodontic management of immature teeth. Study design Relevant studies published through November 2009 were identified through literature searches using Pubmed (Medline) and Scopus databases. Controlled trials in which calcium hydroxide versus mineral trioxide aggregate were used for the apexification of immature permanent teeth were selected for this study. The evaluation included clinical outcome and apical barrier formation. The principal measure of treatment effect was risk difference. The overall effect was tested by using Z score. Heterogeneity was tested by using the χ2 statistic and I square (I2 ). A fixed-effect model was used when the studies in the subgroup were sufficiently similar. A random-effects model was used in the summary analysis when there was heterogeneity between the subgroups. Results Based on reduction of relative risk with 95% confidence intervals we found that the rate of clinical success ( P = .29) and apical barrier formation ( P = .76) of the 2 interventions had no perceivable discrepancy. Regarding success and apical barrier formation, either calcium hydroxide or mineral trioxide aggregate may be used for the apexification of immature teeth.