Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure

FOXO3A and FOXO1A are excellent candidate genes for the development of premature ovarian failure and have not been analyzed previously in POF patients. Potentially causal mutations in FOXO3A (2/90; 2.2%) and FOXO1A (1/90; 1.1%) were identified in POF patients; however, the pathological role of these...

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Bibliographic Details
Published in:	Fertility and sterility Vol. 86; no. 5; p. 1518
Main Authors:	Watkins, Wendy J, Umbers, Alexandra J, Woad, Kathryn J, Harris, Sarah E, Winship, Ingrid M, Gersak, Ksenija, Shelling, Andrew N
Format:	Journal Article
Language:	English
Published:	United States 01-11-2006
Subjects:	DNA Mutational Analysis Female Forkhead Box Protein O1 Forkhead Box Protein O3 Forkhead Transcription Factors - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Genetic Testing - methods Humans Mutation New Zealand - epidemiology Polymorphism, Single Nucleotide Primary Ovarian Insufficiency - epidemiology Primary Ovarian Insufficiency - genetics Risk Assessment - methods Risk Factors Slovenia - epidemiology
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Summary:	FOXO3A and FOXO1A are excellent candidate genes for the development of premature ovarian failure and have not been analyzed previously in POF patients. Potentially causal mutations in FOXO3A (2/90; 2.2%) and FOXO1A (1/90; 1.1%) were identified in POF patients; however, the pathological role of these mutations will be determined only by screening increased numbers of patients and controls, or by functional studies.
ISSN:	1556-5653
DOI:	10.1016/j.fertnstert.2006.03.054