Studies on the protective effect of green tea against cisplatin induced nephrotoxicity

• Published in: Pharmacological research Vol. 60; no. 5; pp. 382 - 391
• Main Authors: Khan, Sara A., Priyamvada, Shubha, Khan, Wasim, Khan, Sheeba, Farooq, Neelam, Yusufi, Ahad N.K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-11-2009
• Subjects: Animals; Antineoplastic Agents - adverse effects; Biological Transport - drug effects; Blood Glucose - metabolism; Carbohydrate metabolism; Cholesterol - blood; Cisplatin; Cisplatin - adverse effects; Creatinine - blood; Green tea; Kidney - drug effects; Kidney - enzymology; Kidney - metabolism; Kidney Cortex - drug effects; Kidney Cortex - enzymology; Lipid Peroxidation - drug effects; Lysosomes - drug effects; Lysosomes - enzymology; Male; Nephrotoxicity; Oxidative damage; Phosphates - metabolism; Pi transport; Rats; Rats, Wistar; Tea - metabolism; Pi transport; Carbohydrate metabolism; Oxidative damage; Nephrotoxicity; Green tea; Cisplatin
• ISSN: 1043-6618; 1096-1186
• DOI: 10.1016/j.phrs.2009.07.007

Cisplatin (CP) an anticancer drug is known to induce nephrotoxicity, which limits its long-term clinical use. Green tea (GT), consumed since ancient times is known for its numerous health benefits. It has been shown to improve kidney functions in animal models of acute renal failure. The present study was undertaken to see whether GT can prevent CP-induced nephrotoxic and other deleterious effects. A nephrotoxic dose of CP was co-administered to control and GT-fed male Wistar rats every fifth day for 25 days. The effect of GT was determined on CP-induced alterations in various serum parameters and on enzymes of carbohydrate metabolism, brush border membrane, and antioxidant defense system in renal cortex and medulla. CP nephrotoxicity was recorded by increased serum creatinine and blood urea nitrogen. CP increased the activities of lactate dehydrogenase and acid phosphatase whereas, the activities of malate dehydrogenase, glucose-6-phosphatase, superoxide dismutase, catalase, and
32Pi transport significantly decreased. GT consumption increased the activities of the enzymes of carbohydrate metabolism, brush border membrane, oxidative stress, and
32Pi transport. GT ameliorated CP-induced nephrotoxic and other deleterious effects due to its intrinsic biochemical/antioxidant properties.