Oculomotor impairment after 1 night of total sleep deprivation : a dissociation between measures of speed and accuracy

• Published in: Clinical neurophysiology Vol. 111; no. 10; pp. 1771 - 1778
• Main Authors: DE GENNARO, Luigi, FERRARA, Michele, URBANI, Luca, BERTINI, Mario
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Science 01-10-2000
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; Electronystagmography; Eye and associated structures. Visual pathways and centers. Vision; Fundamental and applied biological sciences. Psychology; Humans; Male; Polysomnography; Reaction Time - physiology; Saccades - physiology; Sleep Deprivation - physiopathology; Time Factors; Vertebrates: nervous system and sense organs; Human; Ocular motor pathway; Deprivation; Sleep; Electrophysiology; Sleep wake cycle; Pursuit eye movement; Velocity; Adaptation; Saccadic eye movement
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/s1388-2457(00)00393-x

The present study examined the effects of 40 h of sleep deprivation and of time-of-day on saccadic and smooth pursuit oculomotor performance.
Nine normal subjects slept for 3 consecutive nights in the laboratory (one adaptation, one baseline, one recovery). Baseline and recovery were separated by a period of 40 h of continuous wakefulness, during which subjects were tested every 2 h. Oculomotor performance assessed at the following hours: 10:00, 12:00, 14:00, 16:00, 18:00, 20:00, 22:00, of both the days preceding and following the sleep deprivation night, as well as at 24:00, 02:00, 04:00, 06:00 and 08:00 h during the deprivation period.
Saccade latency increased and peak velocity decreased significantly during the post-deprivation day; saccadic accuracy was unaffected. As regards smooth pursuit performance, phase (a measure of accuracy) was not affected by sleep loss, while velocity gain significantly decreased during the day that followed the sleep deprivation night. Significant time-of-day effects on the considered oculomotor variables except saccadic accuracy were also found, indicating an overall performance impairment during the night.
It is concluded that 40 h of sleep deprivation significantly impaired diurnal performance in pursuit and saccadic tasks. This performance worsening is limited to the measures of speed, while accuracy is not affected by sleep loss. A significant operational relevance of these results is suggested, since saccadic velocity has recently been found to be negatively correlated with simulator vehicle crash rates.