Prechallenge Antibodies Moderate Disease Expression in Adults Experimentally Exposed to Rhinovirus Strain Hanks

• Published in: Clinical infectious diseases Vol. 27; no. 1; pp. 119 - 128
• Main Authors: Alper, Cuneyt M., Doyle, William J., Skoner, David P., Buchman, Craig A., Cohen, Sheldon, Gwaltney, Jack M.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Chicago, IL The University of Chicago Press 01-07-1998; University of Chicago Press
• Subjects: Adult; Analysis of Variance; Antibodies; Antibodies, Viral - immunology; Biological and medical sciences; Clinical Articles; Cloisters; Double-Blind Method; Female; Human rhinovirus; Human viral diseases; Humans; Infections; Infectious diseases; Male; Medical sciences; Middle Aged; Middle ear pressure; Mucociliary clearance; Neutralization Tests; Picornaviridae Infections - immunology; Picornaviridae Infections - physiopathology; Rhinovirus; Rhinovirus - immunology; Secretion; Symptoms; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Viruses; Volunteerism; Human; Immunoprotection; Nose disease; Picornaviridae; Antibody; Pathogenesis; Common cold; Homotypy; Infection; Virus; Symptomatology; Experimental disease; Viral disease; ENT disease; Adult; Rhinovirus
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/514634

This double-blind study determined the influence of serum neutralizing antibody titers on the rate of infection and magnitude of disease expression after experimental exposure of adult volunteers to rhinovirus strain Hanks (RV-H). A total of 133 healthy volunteers were tested for antibody status, cloistered for a 6-day period, and challenged with RV-H at the end of the first cloister day. On these days, response to viral challenge is assessed with symptom diaries and physical examinations. The low-titer infected group was significantly different from the intermediate-titer infected and the uninfected groups in terms of postchallenge nasal and throat symptoms, expelled secretion weights, nasal mucociliary clearance rates, and frequency of negative middle ear pressures. A similar trend held for the infected high-titer vs. low-titer group comparisons. These data show that high homotypic serum neutralizing antibody titers are associated with protection from infection and lessened signs and symptoms following experimental RV-H exposure.