Application value of diffusional kurtosis imaging (DKI) in evaluating microstructural changes in the spinal cord of patients with early cervical spondylotic myelopathy

• Published in: Clinical neurology and neurosurgery Vol. 156; pp. 71 - 76
• Main Authors: Li, Daowei, Wang, Xiaoming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-05-2017; Elsevier Limited
• Subjects: Adult; Aged; Anisotropy; Axial diffusion; Axial stress; Brain; Brain injury; Cell membranes; Central nervous system diseases; Cervical spondylosis; Cervical spondylotic myelopathy; Cervical Vertebrae - diagnostic imaging; Compression; Data processing; Differential diagnosis; Diffusion coefficient; Diffusion kurtosis imaging; Diffusion Magnetic Resonance Imaging - methods; Diffusion tensor imaging; Disease; Echo-Planar Imaging; Female; Females; Gray Matter - diagnostic imaging; Head and neck; High resolution; Histopathology; Hum; Humans; Hydrocephalus; Image processing; Image Processing, Computer-Assisted - methods; Injuries; Intervertebral discs; Kurtosis; Leading edges; Lesions; Liver; Magnetic resonance imaging; Male; Males; Membranes; Microstructure; Middle Aged; Multiple sclerosis; Neck; Neck injuries; Neuroimaging; Neurology; Neurosurgery; NMR; Nuclear magnetic resonance; Organelles; Pyramidal tracts; Resonance; Spinal cord; Spinal Cord - diagnostic imaging; Spinal Cord Diseases - diagnostic imaging; Spine; Spondylolisthesis - diagnostic imaging; Stimulation; Substantia alba; Substantia grisea; Sun; Surgery; Tumors; Urinary bladder; White Matter - diagnostic imaging; Young Adult; Cervical spondylosis; Spinal cord; Cervical spondylotic myelopathy; Diffusion kurtosis imaging; Diffusion tensor imaging
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2017.03.015

Highlights • The use of DKI in the spinal cord is relatively understudied. • MK can reflect microstructural changes of white matter and gray matter of spinal cord in early CSM. • MK has the potential to provide new information prior to conventional diffusion metrics such as MD and FA. • Our study provides a reference for early diagnosis, treatment, and prognosis of CSM.