Association between inflammation, lipid and hemostatic factors in patients with stable angina

• Published in: Thrombosis research Vol. 120; no. 1; pp. 53 - 59
• Main Authors: Sagastagoitia, José D, Sáez, Yolanda, Vacas, Marta, Narváez, Idoia, Sáez de Lafuente, Jesús P, Molinero, Enrique, Magro, Ana, Lafita, Manuel, Santos, Mónica, Escobar, Antonio, Iriarte, José A
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 01-01-2007; Elsevier Science
• Subjects: Aged; Angina Pectoris - blood; Angina Pectoris - etiology; Apolipoprotein A-I - blood; Apolipoprotein B-100 - blood; Atherosclerosis - etiology; Biological and medical sciences; Blood and lymphatic vessels; C-Reactive Protein - metabolism; Cardiology. Vascular system; Case-Control Studies; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Coronary heart disease; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Fibrin Fibrinogen Degradation Products - metabolism; Fibrinogen - metabolism; General and cellular metabolism. Vitamins; Heart; Hematology, Oncology and Palliative Medicine; Hemostatic factors; Humans; Inflammation; Lipids; Lipoprotein(a) - blood; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Risk Factors; Stable angina; Thrombosis; Triglycerides - blood; CRP; C-reactive protein; body mass index; apolipoprotein B100; Stable angina; Lipids; Inflammation; apolipoprotein A1; LDLc; Thrombosis; Lp(a); LDL-cholesterol; HDLc; Hemostatic factors; HDLC-cholesterol; Apo A1; lipoprotein(a); Apo B100; BMI; Human; Hemostatic; Metabolic diseases; Cardiovascular disease; Cholesterol LDL; Angina pectoris; D dimer; Triglyceride; Coronary heart disease; Vascular disease; Lipoprotein LDL; Apolipoprotein A; Cholesterol HDL; Atherosclerosis; Fibrinogen; Complication; Dyslipemia; Lipoprotein HDL; C reactive protein
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2006.06.013

Abstract Introduction Dyslipidemia and thrombotic processes are both clearly involved in atherogenesis and its secondary complications. Moreover, inflammation has also been shown to play an important role in the pathophysiology of atherosclerosis. Our objective was to determine the association between inflammation, lipids and thrombosis in a group of patients with stable angina. Patients and methods 295 patients (217 males and 78 females) with a mean age of 65.69 ± 11.24 years. Levels of C-reactive protein, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, lipoprotein(a), apolipoproteins A1 and B100, fibrinogen and D-dimer were determined for each. Results Arithmetic and geometric means of C-reactive protein in the sample were 10.7 and 1.4 mg/l, respectively. Distributing the sample by quartiles of C-reactive protein, we found a positive correlation between C-reactive protein, fibrinogen and D-dimer levels ( p < 0.000), and an inverse correlation for HDL cholesterol and apolipoprotein A1 ( p < 0.000). In multivariate analysis, fibrinogen ( p < 0.000) and D-dimer ( p < 0.01) levels were independently associated with high levels of C-reactive protein. Of the lipid factors, only apolipoprotein A1 ( p < 0.000) was independently and inversely associated with high levels of C-reactive protein. Conclusions These data confirm the association between prothrombotic and inflammatory states and suggest the anti-inflammatory effect of apolipoprotein A1.