Exploring the clinical implications and applications of exosomal miRNAs in gliomas: a comprehensive study

• Published in: Cancer cell international Vol. 24; no. 1; pp. 323 - 18
• Main Authors: Yang, Liang, Niu, Zhen, Ma, Zhixuan, Wu, Xiaojie, Vong, Chi Teng, Li, Ge, Feng, Ying
• Format: Journal Article
• Language: English
• Published: England BioMed Central 27-09-2024; BMC
• Subjects: Diagnosis; Exosomal microRNAs; Glioma; Prognosis; Review; Treatment; Exosomal microRNAs; Prognosis; Treatment; Diagnosis; Glioma
• ISSN: 1475-2867; 1475-2867
• DOI: 10.1186/s12935-024-03507-x

Gliomas are aggressive brain tumors associated with poor prognosis and limited treatment options due to their invasive nature and resistance to current therapeutic modalities. Research suggests that exosomal microRNAs have emerged as key players in intercellular communication within the tumor microenvironment, influencing tumor progression and therapeutic responses. Exosomal microRNAs (miRNAs), small non-coding RNAs, are crucial in glioma development, invasion, metastasis, angiogenesis, and immune evasion by binding to target genes. This comprehensive review examines the clinical relevance and implications of exosomal miRNAs in gliomas, highlighting their potential as diagnostic biomarkers, therapeutic targets and prognosis biomarker. Additionally, we also discuss the limitations of current exsomal miRNA treatments and address challenges and propose future directions for leveraging exosomal miRNAs in precision oncology for glioma management.