Application of adjunct techniques in cytologic material in the diagnosis of rhabdomyosarcoma: Case report and review of the literature

A 4½‐yr‐old female presented with right‐sided pleural effusion and a retroperitoneal mass. Cytologic analysis of the pleural fluid yielded malignant small round blue cells, which were noncohesive, 3–4 times the size of lymphocytes. The malignant cells had hyperchromatic, pleomorphic nuclei with mode...

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Bibliographic Details
Published in:Diagnostic cytopathology Vol. 26; no. 6; pp. 384 - 386
Main Authors: Bhattacharya, Baishali, Sariya, Dinesh, Reddy, Vijaya B., Kluskens, Larry, Gould, Victor E., Gattuso, Paolo
Format: Journal Article
Language:English
Published: New York Wiley Subscription Services, Inc., A Wiley Company 01-06-2002
Wiley-Liss
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Summary:A 4½‐yr‐old female presented with right‐sided pleural effusion and a retroperitoneal mass. Cytologic analysis of the pleural fluid yielded malignant small round blue cells, which were noncohesive, 3–4 times the size of lymphocytes. The malignant cells had hyperchromatic, pleomorphic nuclei with moderate amounts of vacuolated cytoplasm. A few fiber‐shaped cells were also seen. Immunostains for desmin, muscle‐specific actin were positive; ultrastructural findings of thick and thin actin‐myosin filaments confirmed the diagnosis of embryonal rhabdomyosarcoma. This case illustrates the importance of performing appropriate immunohistochemical stains and ultrastructural studies on cytological material to arrive at a definitive diagnosis. Diagn. Cytopathol. 2002;26:384–386. © 2002 Wiley‐Liss, Inc.
Bibliography:ArticleID:DC10069
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ObjectType-Case Study-3
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ISSN:8755-1039
1097-0339
DOI:10.1002/dc.10069