Tumoral volume measured preoperatively by magnetic resonance imaging is related to survival in endometrial cancer

• Published in: Radiology and oncology Vol. 55; no. 1; pp. 35 - 41
• Main Authors: Coronado, Pluvio J., Santiago-López, Javier de, Santiago-García, Javier de, Méndez, Ramiro, Fasero, Maria, Herraiz, Miguel A.
• Format: Journal Article
• Language: English
• Published: Poland Sciendo 12-01-2021; De Gruyter Poland
• Subjects: Cancer; Diameters; Endometrial cancer; Endometrium; Lymph nodes; magnetic resonance image; Magnetic resonance imaging; Medical imaging; Metastases; Multivariate analysis; Myometrium; Patients; recurrence; Resonance; Surgery; Survival; tumoral volume; Tumors; recurrence; endometrial cancer; magnetic resonance image; tumoral volume; survival
• ISSN: 1581-3207; 1318-2099; 1581-3207; 0485-893X
• DOI: 10.2478/raon-2020-0064

The aim of the study was to determine if the endometrial tumor volume (TV) measured by magnetic resonance imaging (MRI-TV) is associated with survival in endometrial cancer and lymph nodes metastases (LN+).
We evaluated the MRI imaging and records of 341 women with endometrial cancer and preoperative MRI from 2008 to 2018. The MRI-TV was calculated using the ellipsoid formula measuring three perpendicular tumor diameters. Tumor myometrial invasion was also analyzed.
Higher MRI-TV was associated with age ≥ 65y, non-endometrioid tumors, grade-3, deep-myometrial invasion, LN+ and advanced FIGO stage. There were 37 patients with LN+ (8.8%). Non-endometrioid tumors, deep-myometrial invasion, grade-3 and MRI-TV ≥ 10 cm
were the factors associated with LN+. Using a receiver operating characteristic [ROC] curve, the MRI-TV cut-off for survival was 10 cm
(area under curve [AUC] = 0.70; 95% CI: 0.61-0.73). 5 years disease-free (DFS) and overall survival (OS) was significantly lower in MRI-TV ≥ 10 cm
(69.3%
. 84.5%, and 75.4%
. 96.1%, respectively). MRI-TV was considered an independent factor of DFS (HR: 2.20, 95% CI: 1.09-4.45, p = 0.029) and OS (HR: 3.88, 95% CI: 1.34-11.24, p = 0.012) in multivariate analysis.
MRI-TV was associated with LN+, and MRI-TV ≥ 10 cm
was an independent prognostic factor of lower DFS and OS. The MRI-TV can be auxiliary information to plan the surgery strategy and predict the adjuvant treatment in women with endometrial cancer.