Endoscopic scoring of late gastrointestinal mucosal damage after adjuvant radiochemotherapy

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 27; pp. 4411 - 4415
• Main Author: Dabak, Resat
• Format: Journal Article
• Language: English
• Published: United States Department of Family Medicine,Kartal State Hospital, Kartal, Istanbul, Turkey%Department of Gastroenterology, Kartal State Hospital, Kartal,Istanbul, Turkey%Department of Radiation Oncology, Kartal State Hospital, Kartal,Istanbul, Turkey%Department of Pathology, Kartal State Hospital,Kartal,Istanbul, Turkey%Department of General Surgery, Kartal State Hospital, Kartal,Istanbul, Turkey 21-07-2006; Baishideng Publishing Group Co., Limited
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - pathology; Adenocarcinoma - radiotherapy; Adult; Aged; Chemotherapy, Adjuvant - adverse effects; Combined Modality Therapy; Endoscopy, Gastrointestinal - statistics & numerical data; Female; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - pathology; Gastrointestinal Tract - radiation effects; Humans; Injury Severity Score; Intestinal Mucosa - drug effects; Intestinal Mucosa - pathology; Intestinal Mucosa - radiation effects; Male; Middle Aged; Radiation Injuries - classification; Radiotherapy, Adjuvant - adverse effects; Rapid Communication; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Stomach Neoplasms - radiotherapy; 内窥镜; 放射化学疗法; 胃肠黏膜损伤; Gastrointestinal mucositis; Endoscopy; Gastric cancer; Radiochemotherapy
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i27.4411

AIM： To evaluate late effects of chemoradiation on gastrointestinal mucosa with an endoscopic scoring system and compare it to a clinical scoring system.
METHODS： Twenty-four patients going to receive chemoradiation after gastric surgery underwent endoscopy four wk after surgery and one year after the chemoradiation finished. Upper gastrointestinal findings were recorded according to a system proposed by World Organisation for Digestive Endoscopy （OMED） and clinical scoring was done with RTOG-EORTC radiation morbidity scoring systems.
RESULTS： There was no significant endoscopic difference in gastric and intestinal mucosa after chemoradiation （P 〉 0.05） and there was no association between endoscopic scores and clinical scores. Endoscopic changes were minimal.
CONCLUSION： Late effects after chemoradiation in operated patients with gastric cancers can be evaluated with an endoscopic scoring system objectively and this system is superior to clinical scoring systems.