Morphology of protein particles produced by spray freezing of concentrated solutions

The mechanisms for the formation of high surface area lysozyme particles in spray freezing processes are described as a function of spray geometry and atomization, solute concentration and the calculated cooling rate. In the spray freeze-drying (SFD) process, droplets are atomized into a gas and the...

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Bibliographic Details
Published in:	European journal of pharmaceutics and biopharmaceutics Vol. 65; no. 2; pp. 149 - 162
Main Authors:	Engstrom, Josh D., Simpson, Dale T., Lai, Edwina S., Williams, Robert O., Johnston, Keith P.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-02-2007 Elsevier Science
Subjects:	Algorithms Biological and medical sciences Freezing General pharmacology Humidity Leidenfrost effect Liquid cryogen Medical sciences Microscopy, Electron, Scanning Muramidase - chemistry Nitrogen Particle Size Pentanes Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders Proteins - chemistry Solutions Spray freeze-drying (SFD) Spray freezing into liquid (SFL) Trehalose Viscosity Spray freezing into liquid (SFL) Liquid cryogen Spray freeze-drying (SFD) Leidenfrost effect Particle Freeze drying Pharmaceutical technology Morphology Spray drying Freezing Protein Solution
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