High-Dose Ampicillin Plus Streptomycin for Treatment of a Patient with Severe Infection Due to Multiresistant Enterococci

• Published in: Clinical infectious diseases Vol. 25; no. 5; pp. 1269 - 1270
• Main Authors: Dodge, Rosemary A., Daly, Jennifer S., Davaro, Raul, Glew, Richard H.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01-11-1997; University of Chicago Press
• Subjects: Abscesses; Ampicillin - therapeutic use; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antibiotics; Ascitic Fluid; Biological and medical sciences; Blood; Brief Reports; Dosage; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; Emergency and intensive care: renal failure. Dialysis management; Enterococcus faecium - drug effects; Gram-Positive Bacterial Infections - drug therapy; Humans; Infections; Intensive care medicine; Labor standards; Male; Medical sciences; Middle Aged; Penicillin; Streptomycin - therapeutic use; Surgical Wound Infection - drug therapy; Human; Drug combination; Streptomycin; Peritoneal dialysis; Infection; Case study; Penicillin derivatives; Extrarenal dialysis; Streptococcaceae; Enterococcus faecium; Antibiotic; Chemotherapy; Treatment; Ampicillin; Abdominal disease; Aminoglycoside; Multiple resistance; Bacteriosis; Bacteria; Micrococcales; Complication; High dose; Peritonitis
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/516977

Treatment options for patients infected with multiply resistant Enterococcus faecium are limited. We describe a patient with intraabdominal and bacteremic infection due to E. faecium that was resistant to vancomycin, ampicillin, and high levels of gentamicin but susceptible to streptomycin. The severity of his infection led us to perform in vitro studies to help predict in vivo response as a guide to managing antibiotic therapy.