The nervous system and chronic kidney disease in children

• Published in: Pediatric nephrology (Berlin, West) Vol. 19; no. 8; pp. 832 - 839
• Main Authors: Gipson, Debbie S, Wetherington, Crista E, Duquette, Peter J, Hooper, Stephen R
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01-08-2004; Springer-Verlag
• Subjects: Adolescent; Aluminum; Anemia; Atrophy; Child; Child development; Child, Preschool; Children; Cognition & reasoning; Cognitive ability; Congenital diseases; Cross-sectional studies; Electroencephalography; Electrophysiology; Hemodialysis; Humans; Infant; Kidney diseases; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - physiopathology; Kidney transplants; Literature reviews; Magnetic resonance imaging; Medical imaging; Nervous system; Nervous System - growth & development; Nervous System - physiopathology; Nervous System Diseases - etiology; Neuroimaging; Neuropsychology; Pediatrics; Peritoneal dialysis; Review; Teenagers; North Carolina; United States > US
• ISSN: 0931-041X; 1432-198X
• DOI: 10.1007/s00467-004-1532-y

This paper provides a review of the literature on the nervous system involvement incurred by children and adolescents with chronic kidney disease (CKD), with a particular focus on neuropsychological functioning. In addition to an historical overview of earlier literature, published studies from the past 14 years that address both central and peripheral nervous system function in children with CKD are reviewed (1990-2003). These studies span work in neuroimaging, electrophysiology, and neuropsychology. A key focus for this review is on variables that might affect neurodevelopmental status in these children. The paper concludes with suggestions for achieving progress in the understanding of this complication of kidney disease in children.