The role of variants from the innate immune system genes in tuberculosis and skin test response in a Native American population

• Published in: Human immunology Vol. 77; no. 10; pp. 981 - 984
• Main Authors: Lindenau, Juliana D, Salzano, Francisco M, Hurtado, Ana M, Hill, Kim R, Hutz, Mara H
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-10-2016
• Subjects: Adult; Allergy and Immunology; Amerindians; CR1; Female; Genetic Predisposition to Disease; Humans; Immunity, Innate - genetics; Indians, South American; Innate immunity; Male; Middle Aged; Mycobacterium; Paraguay; Polymorphism, Single Nucleotide; Receptors, Complement - genetics; TLR9; Toll-Like Receptor 9 - genetics; Tuberculin Test; Tuberculosis; Tuberculosis, Pulmonary - genetics; Young Adult; TLR9; Amerindians; Innate immunity; Tuberculosis; CR1
• ISSN: 0198-8859; 1879-1166
• DOI: 10.1016/j.humimm.2016.06.017

Abstract Native American populations show higher tuberculosis (TB) mortality and infectivity rates than non-Native populations. Variants in the innate immune system seem to have an important role on TB susceptibility. The role of some innate immune system variants in TB susceptibility and/or skin test response (PPD) were investigated in the Aché, a Native American population. Complement receptor 1 and toll like receptor 9 variants were associated with anergy to PPD and protection to TB, respectively. These findings demonstrate an important role of the innate immune system variants in TB susceptibility.