HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 194 Southeast Asia Chinese from Peninsular Malaysia

• Published in: Human immunology Vol. 80; no. 11; pp. 906 - 907
• Main Authors: Too, Chun-Lai, Tan, Lay-Kim, Heselynn, Hussein, Nor-Shuhaila, Shahril, Eashwary, Mageswaran, Wahinuddin, Sulaiman, Lau, Ing Soo, Gun, Suk Chyn, Mohd-Shahrir, Mohamed-Said, Ainon, Mohd-Mokhtar, Azmillah, Rosman, Muhaini, Othman, Shahnaz, Murad
• Format: Journal Article Conference Proceeding
• Language: English
• Published: United States Elsevier Inc 01-11-2019
• Subjects: Alleles; Asia, Southeastern; Asian Continental Ancestry Group; Gene Frequency; Genetics, Population; Genotype; Haplotypes; Histocompatibility Testing; HLA-A Antigens - genetics; HLA-B Antigens - genetics; HLA-C Antigens - genetics; HLA-DQ beta-Chains - genetics; HLA-DRB1 Chains - genetics; Humans; Malaysia; Medicin och hälsovetenskap; Asia, Southeastern; Malaysia
• ISSN: 0198-8859; 1879-1166; 1879-1166
• DOI: 10.1016/j.humimm.2019.09.005

A total of 194 Southeast Asia Chinese from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, the HLA-B, HLA-DRB1 and HLA-DQB1 were in Hardy-Weinberg proportions (HWEP) (p > 0.05). We observed significant deviation from HWEP in HLA-A (p < 0.05) and HLA-C (p < 0.01) loci. This genotype data was available in Allele Frequencies Network Database (AFND) Dos Santos et al. (2016).