The association of oxidative stress markers with conventional risk factors in the metabolic syndrome

• Published in: Metabolism, clinical and experimental Vol. 62; no. 6; pp. 828 - 835
• Main Authors: Korkmaz, Gulcan G, Altınoglu, Esma, Civelek, Sabiha, Sozer, Volkan, Erdenen, Füsun, Tabak, Omur, Uzun, Hafize
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-06-2013; Elsevier
• Subjects: Adult; Advanced Oxidation Protein Products - blood; Advanced protein oxidation products; Antioxidants - metabolism; Biological and medical sciences; Biomarkers - blood; Case-Control Studies; Endocrinology & Metabolism; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Humans; Logistic Models; Male; Medical sciences; Metabolic diseases; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - physiopathology; Middle Aged; Miscellaneous; Other metabolic disorders; Oxidants - blood; Oxidative Stress; Pro-oxidant–antioxidant balance; Risk Factors; ROC Curve; Total antioxidant capacity; Vertebrates: anatomy and physiology, studies on body, several organs or systems; coronary artery disease; NAFLD; high density lipoprotein-cholesterol; RAS; renin–angiotensin system; AUC; HDL-C; non-alcoholic fatty-liver disease; reactive oxygen species; FRAP; receiver operating characteristic; insulin resistance; homeostasis model assessment; BMI; ORAC; oxygen radical absorbance capacity; body mass index; pro-oxidant antioxidant balance; CAD; ROC; IR; area under the curve; Pro-oxidant–antioxidant balance; metabolic syndrome; AOPP; PAB; MetS; total antioxidant capacity; TAC; ROS; ferric reducing antioxidant power; HOMA; advanced protein oxidation products; Total antioxidant capacity; Metabolic syndrome; Advanced protein oxidation products; Endocrinopathy; Oxidative stress; Association; Risk factor; Metabolic diseases; Cardiovascular disease; Marker; Endocrinology
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/j.metabol.2013.01.002

Abstract Background and Aims The metabolic syndrome (MetS) is a common and complex disorder that consists of various abnormalities, including dyslipidemia, obesity, hypertension and hyperglycemia. We investigated the relationships between the levels of advanced protein oxidation products (AOPPs), the total antioxidant capacity (TAC) and the pro-oxidant-antioxidant balance (PAB) in MetS patients. Methods A total of 55 patients (37 women, 18 men) with MetS and 20 healthy controls (14 women, 6 men) with a body mass index (BMI) less than 25 kg/m2 were enrolled in the study. Colorimetric methods were used to determine the levels of AOPPs, the TAC, and the PAB. Results AOPP, TAC, and PAB values were significantly higher in patients with MetS than in control subjects (p < 0.001, p = 0.050, and p < 0.001, respectively). A positive correlation was observed between the AOPP levels and the glucose, triglyceride, insulin and HOMA-IR levels. PAB values also exhibited significant positive correlations with diastolic blood pressure and fibrinogen levels. Logistic regression analysis revealed that higher serum PAB values were positively and independently associated with the MetS (odds ratio: 1.110; 95% confidence interval: 1.006–1.224; P < 0.37). Conclusions Increased AOPP levels and higher PAB values are likely to be a result of oxidative stress, a condition in which an imbalance occurs between the production and inactivation of reactive oxygen species. In addition, it appears that serum PAB values may accurately reflect the levels of oxidative stress in MetS patients.