Immunological Pattern in IgA Nephropathy

• Published in: International journal of molecular sciences Vol. 21; no. 4; p. 1389
• Main Authors: Esteve Cols, Clara, Graterol Torres, Freddzia-Amanda, Quirant Sánchez, Bibiana, Marco Rusiñol, Helena, Navarro Díaz, Maruja Isabel, Ara Del Rey, Jordi, Martínez Cáceres, Eva Mª
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 18-02-2020; MDPI AG
• Subjects: biomarkers; cd89; iga nephropathy; monocytes; monocytes; IgA Nephropathy; CD89; biomarkers
• ISSN: 1422-0067; 1422-0067
• DOI: 10.3390/ijms21041389

The current gold-standard diagnostic technique for IgA nephropathy (IgAN), the leading form of primary glomerulonephritis, is renal biopsy. CD89 (the main IgA receptor) is expressed on the surface of monocytes and plays a role in disease pathogenesis. Immunocomplexes formed by sCD89 (soluble form) and Gd-IgA1 are related to disease prognosis. We hypothesize that reduced CD89 surface expression on monocytes may be a marker of disease severity. We aimed to analyze leukocyte subpopulations in peripheral blood and CD89 surface expression on monocytes in a prospective study of 22 patients and 12 healthy subjects (HS). Leukocyte subpopulations and CD89 expression were analyzed by flow cytometry. IgAN patients had a higher percentage of activated and effector memory CD4
and CD8
T lymphocytes, a lower percentage of transitional B lymphocytes and plasmablasts, and a higher percentage of CD56
CD16
NK cells and myeloid dendritic cells compared with HS. Correlations between reduced CD89 expression levels on nonclassical monocytes, histological findings of a poor prognosis on renal biopsy and baseline renal function were observed. IgAN patients show a characteristic immunological pattern in peripheral blood. A reduced expression level of CD89 on nonclassical monocytes identifies patients with a worse renal prognosis.