Split-spectrum phase-gradient optical coherence tomography angiography

• Published in: Biomedical optics express Vol. 7; no. 8; pp. 2943 - 2954
• Main Authors: Liu, Gangjun, Jia, Yali, Pechauer, Alex D, Chandwani, Rahul, Huang, David
• Format: Journal Article
• Language: English
• Published: United States Optical Society of America 01-08-2016
• Subjects: (170.3880) Medical and biological imaging; (170.3340) Laser Doppler velocimetry; (110.4500) Optical coherence tomography; (170.2655) Functional monitoring and imaging
• ISSN: 2156-7085; 2156-7085
• DOI: 10.1364/boe.7.002943

A phase gradient angiography (PGA) method is proposed for optical coherence tomography (OCT). This method allows the use of phase information to map the microvasculature in tissue without the correction of bulk motion and laser trigger jitter induced phase artifacts. PGA can also be combined with the amplitude/intensity to improve the performance. Split-spectrum technique can further increase the signal to noise ratio by more than two times. In-vivo imaging of human retinal circulation is shown with a 70 kHz, 840 nm spectral domain OCT system and a 200 kHz, 1050 nm swept source OCT system. Four different OCT angiography methods are compared. The best performance was achieved with split-spectrum amplitude and phase-gradient angiography.