Activity of Potential Alternative Treatment Agents for Stenotrophomonas maltophilia Isolates Nonsusceptible to Levofloxacin and/or Trimethoprim-Sulfamethoxazole

• Published in: Journal of clinical microbiology Vol. 58; no. 2
• Main Authors: Biagi, M, Tan, X, Wu, T, Jurkovic, M, Vialichka, A, Meyer, K, Mendes, R E, Wenzler, E
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 28-01-2020
• Subjects: Anti-Bacterial Agents - classification; Anti-Bacterial Agents - pharmacology; Bacteriology; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacterial Infections - drug therapy; Humans; Levofloxacin - pharmacology; Microbial Sensitivity Tests; Stenotrophomonas maltophilia - classification; Stenotrophomonas maltophilia - drug effects; Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology; Stenotrophomonas maltophilia; omadacycline; eravacycline; levofloxacin; trimethoprim-sulfamethoxazole; minocycline; delafloxacin
• ISSN: 0095-1137; 1098-660X
• DOI: 10.1128/jcm.01603-19

is difficult to treat due to the production of multiple intrinsic and acquired mechanisms of resistance. Trimethoprim-sulfamethoxazole (TMP-SMZ) and the fluoroquinolones have traditionally been considered the drugs of choice but are plagued by increasing resistance and adverse drug effects. The objective of this study was to evaluate the
activities of 12 clinically relevant antimicrobials against clinical
isolates nonsusceptible to levofloxacin and/or TMP-SMZ. A diverse panel of 41 clinical
isolates collected through the SENTRY Antimicrobial Surveillance Program from 2008 to 2018 was evaluated against ceftazidime, ceftazidime-avibactam, chloramphenicol, delafloxacin, levofloxacin, moxifloxacin, eravacycline, minocycline, omadacycline, polymyxin B, and tigecycline. MICs were determined in triplicate via reference broth microdilution and interpreted according to CLSI guidelines where available. MIC distributions and susceptibilities were also compared across infection type, acquisition setting, and geographic origin. Susceptibilities to levofloxacin and TMP-SMZ were 29.3% and 36.6%, respectively. Minocycline displayed the highest susceptibility rate overall (92.7%) and the lowest MIC
value (4 mg/liter) of any of the 12 agents tested. Only 3 isolates were resistant to levofloxacin, TMP-SMZ, and minocycline. Polymyxin B and tigecycline were the second most active agents. No significant differences were observed in MIC distributions across the 3 strata evaluated. These data demonstrate that few antimicrobials, old or new, maintain reliable activity against resistant
The role of minocycline in the treatment of infections due to
warrants further clinical investigation given its potent
activity and favorable adverse effect profile.