HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 271 Southeast Asia Indians from Peninsular Malaysia

• Published in: Human immunology Vol. 81; no. 6; pp. 263 - 264
• Main Authors: Nurul-Aain, Ahmad Fauzi, Tan, Lay-Kim, Heselynn, Hussein, Nor-Shuhaila, Shahril, Eashwary, Mageswaran, Wahinuddin, Sulaiman, Lau, Ing Soo, Gun, Suk Chyn, Mohd-Shahrir, Mohamed-Said, Ainon, Mohd-Mokhtar, Azmillah, Rosman, Muhaini, Othman, Shahnaz, Murad, Too, Chun-Lai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-06-2020
• Subjects: Alleles; Asia, Southeastern; Asian Continental Ancestry Group; Ethnic Groups; Gene Frequency; Genetics, Population; Genotype; Haplotypes; HLA; HLA-A Antigens - genetics; HLA-B Antigens - genetics; HLA-C Antigens - genetics; HLA-DQ beta-Chains - genetics; HLA-DRB1 Chains - genetics; Humans; India - ethnology; Malaysia - epidemiology; Malaysia - ethnology; Medicin och hälsovetenskap; Peninsular Malaysia; Southeast Asia Indians; Asia, Southeastern; Malaysia; India; Haplotypes; Peninsular Malaysia; HLA; Southeast Asia Indians; Alleles
• ISSN: 0198-8859; 1879-1166; 1879-1166
• DOI: 10.1016/j.humimm.2020.04.004

A total of 271 Southeast Asia Indians from Peninsular Malaysia were genotyped for HLA-A, -B, -C, -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, HLA-B and HLA-DQB1 was in Hardy-Weinberg proportions (HWEP) (p > 0.05). We observed significant deviation from the HWEP for HLA-A (p < 0.05), HLA-C (p < 0.01) and HLA-DRB1 (p < 0.01) loci. This genotype data is available in Allele Frequencies Network Database (AFND) Dos Santos et al. (2016).