Graphene Oxide-Silver Nanoparticle Nanohybrids: Synthesis, Characterization, and Antimicrobial Properties

• Published in: Nanomaterials (Basel, Switzerland) Vol. 10; no. 2; p. 376
• Main Authors: Cobos, Mónica, De-La-Pinta, Iker, Quindós, Guillermo, Fernández, M Jesús, Fernández, M Dolores
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 21-02-2020; MDPI AG
• Subjects: antimicrobial activity; graphene oxide; nanohybrids; silver nanoparticles; graphene oxide; antimicrobial activity; silver nanoparticles; nanohybrids
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano10020376

Drug resistance of pathogenic microorganisms has become a global public health problem, which has prompted the development of new materials with antimicrobial properties. In this context, antimicrobial nanohybrids are an alternative due to their synergistic properties. In this study, we used an environmentally friendly one-step approach to synthesize graphene oxide (GO) decorated with silver nanoparticles (GO-AgNPs). By this process, spherical AgNPs of average size less than 4 nm homogeneously distributed on the surface of the partially reduced GO can be generated in the absence of any stabilizing agent, only with ascorbic acid (L-AA) as a reducing agent and AgNO
as a metal precursor. The size of the AgNPs can be controlled by the AgNO
concentration and temperature. Smaller AgNPs are obtained at lower concentrations of the silver precursor and lower temperatures. The antimicrobial properties of nanohybrids against Gram-negative bacteria
and
, Gram-positive
, and the yeast
were found to be concentration- and time-dependent.
and
showed the highest susceptibility to GO-AgNPs. These nanohybrids can be used as nanofillers in polymer nanocomposites to develop materials with antimicrobial activity for applications in different areas, and another potential application could be cancer therapeutic agents.