Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide

• Published in: Journal of applied physiology (1985) Vol. 82; no. 1; pp. 111 - 117
• Main Authors: Albert, T. S. E, Tucker, V. L, Renkin, E. M
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01-01-1997; American Physiological Society
• Subjects: Albumins - metabolism; Albumins - physiology; Animals; Apud cells. Peptide and protein hormones. Growth factors; Atrial Natriuretic Factor - metabolism; Biological and medical sciences; Biological Transport; Fundamental and applied biological sciences. Psychology; Hypoxia - metabolism; Hypoxia - physiopathology; Male; Pulmonary Alveoli - metabolism; Rats; Rats, Wistar; Time Factors; Vertebrates: endocrinology; Oxygen; Rat; Biological transport; Rodentia; Albumin; Plasma volume; Environmental factor; Atrial natriuretic peptide; Permeability; Respiratory system; Vertebrata; Natriuretic hormone; Mammalia; Immunoreactive form; Pulmonary alveolus; Hormonal regulation; Hypoxia; Blood capillary; Carrier protein
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1997.82.1.111

T. S. E.
Albert,
V. L.
Tucker, and
E. M.
Renkin
Department of Human Physiology, University of California, Davis,
California 95616
Received 1 February 1996; accepted in final form 4 September 1996.
Albert, T. S. E., V. L. Tucker, and E. M. Renkin. Acute
alveolar hypoxia increases blood-to-tissue albumin transport: role of
atrial natriuretic peptide. J. Appl.
Physiol. 82(1): 111-117, 1997. Plasma
immunoreactive atrial natriuretic peptide (irANP) and blood-to-tissue
clearance of 131 I-labeled rat
serum albumin (C RSA ) were
examined in anesthetized rats during hypoxic ventilation
( n  = 5-7/group). Hypoxia (10 min) increased irANP from 211 ± 29 (room air) to 229 ± 28 (15%
O 2 , not significant), 911 ± 205 (10% O 2 ), and 4,374 ± 961 pg/ml (8% O 2 ),
respectively. Graded increases in
C RSA were significant at 8%
O 2 in fat (3.6-fold), ileum
(2.2-fold), abdominal muscles (2.0-fold), kidney (1.8-fold), and
jejunum (1.4-fold). C RSA was
decreased in back skin and testes; heart, brain, and lungs were
unaffected. The increases in C RSA
were related to irANP and not to arterial P O 2 . Circulating plasma volume was
negatively correlated with whole body
C RSA . Graded increases in
extravascular water content (EVW) were found in the kidney, left heart,
and cerebrum and were positively related to
C RSA in the kidney. EVW decreased in gastrointestinal tissues; the magnitude was inversely related to
C RSA . We conclude that ANP-induced
protein extravasation contributes to plasma volume contraction during
acute hypoxia.
plasma volume; capillary permeability; albumin clearance; edema
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