Pro-Gastrin-Releasing Peptide as a Marker of Small Cell Lung Cancer

• Published in: Bulletin of experimental biology and medicine Vol. 173; no. 2; pp. 257 - 260
• Main Authors: Lyubimova, N. V., Kuz’minov, A. E., Markovich, A. A., Lebedeva, A. V., Timofeev, Yu. S., Stilidi, I. S., Kushlinskii, N. E.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-06-2022; Springer; Springer Nature B.V
• Subjects: Biochemical markers; Biological products; Biology; Biomedical and Life Sciences; Biomedicine; Bones; Brain research; Cell Biology; Diagnosis; Efficiency; Enzymes; Gastrin; Gastrin-releasing peptide; Internal Medicine; Laboratory Medicine; Liver; Liver cancer; Lung cancer; Lung cancer, Small cell; Medical research; Medicine, Experimental; Metastases; Metastasis; Pathology; Peptides; Phosphopyruvate hydratase; Prognosis; Serum levels; Small cell lung carcinoma; Tumors; chromogranin A; pro-gastrin-releasing peptide; neuron-specific enolase; small cell lung cancer; blood serum
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-022-05529-9

The serum levels of pro-gastrin-releasing peptide (proGRP), neuron-specific enolase (NSE), and chromogranin A (CgA) were studied in 69 patients with small cell lung cancer and 50 apparently healthy donors. A significant increase of all studied biochemical markers was revealed in small cell lung cancer patients, while the highest diagnostic efficiency was demonstrated by proGRP compared to NSE and CgA. ProGRP is a promising biochemical marker of small cell lung cancer, especially sensitive in patients with distant metastases (in the brain, liver, and bones).