Computation‐Guided Design of a Stimulus‐Responsive Multienzyme Supramolecular Assembly

The construction of stimulus‐responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one‐pot biotransformations. We have constructed a phosphorylation‐ and...

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Bibliographic Details
Published in:	Chembiochem : a European journal of chemical biology Vol. 18; no. 20; pp. 2000 - 2006
Main Authors:	Yang, Lu, Dolan, Elliott M., Tan, Sophia K., Lin, Tianyun, Sontag, Eduardo D., Khare, Sagar D.
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 18-10-2017
Subjects:	Biodegradation Computer-Aided Design enzymes Models, Molecular Multienzyme Complexes - chemistry Phosphorylation photo-crosslinking Pollutants Propane - analogs & derivatives Propane - chemistry protein design Protein Domains supramolecular enzyme assembly Trichloropropane supramolecular enzyme assembly biodegradation enzymes photo-crosslinking protein design
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Summary:	The construction of stimulus‐responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one‐pot biotransformations. We have constructed a phosphorylation‐ and optically responsive metabolon for the biodegradation of the environmental pollutant 1,2,3‐trichloropropane.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201700425