Increased frequency of cluster of differentiation 14 (CD14+) monocytes expressing interleukin 1 beta (IL-1β) in Alzheimer's disease patients and intermediate levels in late-onset depression patients

• Published in: International journal of geriatric psychiatry Vol. 29; no. 2; pp. 137 - 143
• Main Authors: Torres, Karen Cecília, Lima, Giselle Sabrina, Fiamoncini, Carolina Maciel, Rezende, Vitor Bortolo, Pereira, Patrícia Araújo, Bicalho, Maria Aparecida, Moraes, Edgar Nunes, Romano-Silva, Marco Aurélio
• Format: Journal Article
• Language: English
• Published: Hove Blackwell Publishing Ltd 01-02-2014; Psychology Press; Wiley Subscription Services, Inc
• Subjects: Age of Onset; Aged; Aged, 80 and over; Alzheimer disease; Alzheimer Disease - immunology; Alzheimer's disease; Biological and medical sciences; Case-Control Studies; Cell Differentiation; Cytokines; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; Depressive Disorder - immunology; Female; Flow Cytometry; General aspects; Geriatric psychiatry; Geriatrics; Humans; IL-1beta; Immune system; Immunity, Innate - physiology; Interleukin-1beta - metabolism; late -onset depression; Lipopolysaccharide Receptors - metabolism; Male; Medical sciences; Mental depression; Middle Aged; Monocytes - cytology; Monocytes - immunology; Monocytes - metabolism; Neurology; Patients; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Mood disorder; Human; Nervous system diseases; Monocyte; late -onset depression; Alzheimer disease; Cytokine; Depression; Interleukin 1β; Patient; Cluster; IL-1beta; Cerebral disorder; Gerontology; Geriatric depression; Central nervous system disease; Frequency; Degenerative disease; Differentiation; Elderly; Psychiatry; Geriatrics
• ISSN: 0885-6230; 1099-1166
• DOI: 10.1002/gps.3973

Objective
Depression might be a prodromal stage of dementia. Many factors contribute to the etiology of depression and dementia, being inflammation one of those. The present work measured and analyzed immune molecules involved in the innate immunity on cluster of differentiation 14 (CD14+) monocytes trying to investigate any relationship among late‐onset depression (LOD) and Alzheimer's disease (AD).
Methods
Immune molecules were evaluated in monocytes of AD, LOD patients, and controls using flow cytometry.
Results
Interestingly, interleukin 1 beta (IL‐1β) expressing CD14+ monocytes were increased in AD patients compared with controls. LOD presented intermediate frequency of CD14+ monocytes expressing IL‐1β between controls and AD patients.
Conclusion
Results suggest that an increased frequency of CD14+ monocytes expressing IL‐1β level could be a stage marker related to the pathophysiology of dementia process between normal aging and AD. Copyright © 2013 John Wiley & Sons, Ltd.