Hematopoietic progenitors polarize in contact with bone marrow stromal cells in response to SDF1

The fate of hematopoietic stem and progenitor cells (HSPCs) is regulated by their interaction with stromal cells in the bone marrow. However, the cellular mechanisms regulating HSPC interaction with these cells and their potential impact on HSPC polarity are still poorly understood. Here we evaluate...

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 220; no. 11; p. 1
Main Authors:	Bessy, Thomas, Candelas, Adrian, Souquet, Benoit, Saadallah, Khansa, Schaeffer, Alexandre, Vianay, Benoit, Cuvelier, Damien, Gobaa, Samy, Nakid-Cordero, Cecilia, Lion, Julien, Bories, Jean-Christophe, Mooney, Nuala, Jaffredo, Thierry, Larghero, Jerome, Blanchoin, Laurent, Faivre, Lionel, Brunet, Stephane, Théry, Manuel
Format:	Journal Article
Language:	English
Published:	United States Rockefeller University Press 01-11-2021
Subjects:	Biomedical materials Bone marrow Bone Marrow - metabolism Bone Marrow - physiology Cell Behavior Cells, Cultured Cellular Biology Chemokine CXCL12 - metabolism Cytoskeleton Endothelial cells Endothelial Cells - metabolism Endothelial Cells - physiology Fibroblasts Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - physiology Humans Life Sciences Mesenchymal Stem Cells - metabolism Mesenchymal Stem Cells - physiology Myeloid cells Polarity Polarization Progenitor cells SDF-1 protein Stem Cells Stromal cells
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