ADCC and complement-dependent lysis as immune mechanisms against EHV-1 infection in the horse

Immunity to equine herpesvirus type 1 (EHV-1) was evaluated using sera collected from yearling horses involved in a trial of a commercial vaccine. Measurement of the ability of these sera to mediate antibody-dependent cellular cytotoxicity and complement-dependent lysis revealed that these mechanism...

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Bibliographic Details
Published in:	Research in veterinary science Vol. 44; no. 3; p. 295
Main Authors:	Stokes, A, Wardley, R C
Format:	Journal Article
Language:	English
Published:	England 01-05-1988
Subjects:	Animals Antibody-Dependent Cell Cytotoxicity Complement System Proteins - immunology Herpesviridae Infections - immunology Herpesviridae Infections - prevention & control Herpesviridae Infections - veterinary Herpesvirus 1, Equid Horse Diseases - immunology Horse Diseases - microbiology Horse Diseases - prevention & control Horses Viral Vaccines
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Summary:	Immunity to equine herpesvirus type 1 (EHV-1) was evaluated using sera collected from yearling horses involved in a trial of a commercial vaccine. Measurement of the ability of these sera to mediate antibody-dependent cellular cytotoxicity and complement-dependent lysis revealed that these mechanisms, although potentially important in recovery from EHV-1 infection, do not play a role in protection following vaccination.
ISSN:	0034-5288
DOI:	10.1016/S0034-5288(18)30860-9