Long-Term Outcome After Ablation of Right Atrial Tachyarrhythmias After the Surgical Repair of Congenital and Acquired Heart Disease

• Published in: The American journal of cardiology Vol. 115; no. 12; pp. 1705 - 1713
• Main Authors: Anguera, Ignasi, MD, PhD, Dallaglio, Paolo, MD, Macías, Rosa, MD, Jiménez-Candil, Javier, MD, PhD, Peinado, Rafael, MD, García-Seara, Javier, MD, Arcocha, Mari Fe, MD, Herreros, Benito, MD, Quesada, Aurelio, MD, Hernández-Madrid, Antonio, MD, Alvarez, Miguel, MD, Filgueiras, David, MD, Matía, Roberto, MD, Cequier, Angel, MD, PhD, Sabaté, Xavier, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15-06-2015; Elsevier Limited
• Subjects: Cardiac arrhythmia; Cardiac Surgical Procedures; Cardiovascular; Cardiovascular disease; Catheter Ablation; Catheters; Coronary vessels; Electrophysiologic Techniques, Cardiac; Female; Heart Atria - physiopathology; Heart Atria - surgery; Heart Defects, Congenital - physiopathology; Heart Defects, Congenital - surgery; Heart Diseases - physiopathology; Heart Diseases - surgery; Heart failure; Hospitals; Humans; Male; Middle Aged; Mortality; Multivariate analysis; Pulmonary arteries; Retrospective Studies; Spain; Standard deviation; Success; Surgery; Tachycardia - physiopathology; Tachycardia - surgery; Treatment Outcome; Variables; Spain
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2015.03.017

Atrial myopathy, atriotomies, and fibrotic scars are the pathophysiological substrate of lines of conduction block, promoting atrial macroreentry. The aim of this study was to determine the acute and long-term outcome of radiofrequency catheter ablation (RFCA) for right atrial tachyarrhythmia (AT) in adults after cardiac surgery for congenital heart disease (CHD) and acquired heart disease (AHD) and predictors of these outcomes. Clinical records of adults after surgery for heart disease undergoing RFCA of right-sided AT were analyzed retrospectively. Multivariate analyses identified clinical and procedural factors predicting acute and long-term outcomes. A total of 372 patients (69% men; age 61 ± 15 years) after surgical repair of CHD (n = 111) or AHD (n = 261) were studied. Cavotricuspid isthmus–dependent atrial flutter (CTI-AFL) was observed in 300 patients and non-CTI-AFL in 72 patients. Ablation was successful in 349 cases (94%). During a mean follow-up of 51 ± 30 months, recurrences were observed in 24.5% of patients. Multivariate analysis showed that non-CTI-AFL (hazard ratio [HR] 1.78, 95% confidence interval [CI] 1.1 to 2.9) and CHD (HR 1.75, 95% CI 1.07 to 2.9) were independent predictors of long-term recurrences. Multivariate analysis showed that female gender (HR 2.29, 95% CI 1.6 to 3.3), surgery for AHD (HR 95% 2.31, 95% CI 1.5 to 3.7), and left atrial dilatation (HR 2.1, 95% CI 1.3 to 3.2) were independent predictors of long-term atrial fibrillation. In conclusion, RFCA of right-sided AT after cardiac surgery is associated with high acute success rates and significant long-term recurrences. Non–CTI-dependent AFL and surgery for CHD are at higher risk of recurrence. Atrial fibrillation is common during follow-up, particularly in patients with AHD and enlarged left atrium.