Cardiac Contractility during Severe Ketoacidosis
To the Editor: Experimental studies suggest that metabolic acidosis impairs the contractile function of the heart, but whether this occurs in humans is uncertain. 1 , 2 During a six-month period, we measured fractional shortening of the left ventricle during systole in 10 consecutive patients (6 wom...
Saved in:
| Published in: | The New England journal of medicine Vol. 341; no. 25; p. 1938 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Massachusetts Medical Society
16-12-1999
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | To the Editor:
Experimental studies suggest that metabolic acidosis impairs the contractile function of the heart, but whether this occurs in humans is uncertain.
1
,
2
During a six-month period, we measured fractional shortening of the left ventricle during systole in 10 consecutive patients (6 women and 4 men; mean [±SD] age, 42±18 years), 7 of whom were admitted for treatment of diabetic ketoacidosis and 3 of whom were admitted for alcoholic ketoacidosis. We focused on these conditions because the ketoacidosis associated with them, although frequently severe, is usually rapidly reversible.
Treatment included intravenous rehydration (mean volume of fluid infused, 3.1±1.6 . . . |
|---|---|
| Bibliography: | SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2 |
| ISSN: | 0028-4793 1533-4406 |
| DOI: | 10.1056/NEJM199912163412516 |