Molecular tools for recording and intervention of neuronal activity

Observing the activity of neural networks is critical for the identification of learning and memory processes, as well as abnormal activities of neural circuits in disease, particularly for the purpose of tracking disease progression. Methodologies for describing the activity history of neural netwo...

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Bibliographic Details
Published in:	Molecules and cells Vol. 47; no. 4; pp. 100048 - 9
Main Authors:	Eom, Kisang, Jung, Jinhwan, Kim, Byungsoo, Hyun, Jung Ho
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-04-2024 Korean Society for Molecular and Cellular Biology 한국분자세포생물학회
Subjects:	Calcium and Light-Induced Gene Handling Toolkit Minireview Molecular engineering Neural ensembles Optogenetics Tagging 생물학 Calcium and Light-Induced Gene Handling Toolkit Tagging Molecular engineering Optogenetics Neural ensembles
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Summary:	Observing the activity of neural networks is critical for the identification of learning and memory processes, as well as abnormal activities of neural circuits in disease, particularly for the purpose of tracking disease progression. Methodologies for describing the activity history of neural networks using molecular biology techniques first utilized genes expressed by active neurons, followed by the application of recently developed techniques including optogenetics and incorporation of insights garnered from other disciplines, including chemistry and physics. In this review, we will discuss ways in which molecular biological techniques used to describe the activity of neural networks have evolved along with the potential for future development.
Bibliography:	These authors contributed equally.
ISSN:	1016-8478 0219-1032
DOI:	10.1016/j.mocell.2024.100048