Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications

Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications

Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and promoting the resolution of inflammation. Our purpos...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 27; no. 15; p. 4836
Main Authors: Valente, Mariarosaria, Dentoni, Marta, Bellizzi, Fabrizio, Kuris, Fedra, Gigli, Gian Luigi
Format: Journal Article
Language:English
Published: Basel MDPI AG 28-07-2022
MDPI
Subjects:
annexins
Biosynthesis
Chemokines
Edema
Fatty acids
Homeostasis
Inflammation
Kinases
Lipids
lipoxins
maresins
Metabolism
Neurological diseases
Phosphorylation
protectins
Proteins
resolvins
Review
specialized pro-resolving mediators
Tissue engineering
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Description
Summary:Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and promoting the resolution of inflammation. Our purpose was to point out the current evidence for specialized pro-resolving mediators, focusing on their role in neuroinflammation and in major neurological diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27154836