Serum levels of apoptosis biomarkers, survivin and TNF-alpha in nonsmall cell lung cancer

• Published in: Lung cancer (Amsterdam, Netherlands) Vol. 59; no. 2; pp. 240 - 245
• Main Authors: Derin, Duygu, Soydinç, Hilal Oguz, Guney, Nese, Tas, Faruk, Çamlıca, Hakan, Duranyıldız, Derya, Yasasever, Vildan, Topuz, Erkan
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01-02-2008; Elsevier Science
• Subjects: Adult; Aged; Apoptosis; Apoptosis - physiology; Biological and medical sciences; Biomarkers, Tumor - blood; Carcinoma, Non-Small-Cell Lung - blood; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - pathology; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Hematology, Oncology and Palliative Medicine; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms - blood; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Male; Medical sciences; Microtubule-Associated Proteins - blood; Middle Aged; Neoplasm Proteins - blood; Neoplasm Staging; Nonsmall cell lung cancer; Platinum Compounds - therapeutic use; Pneumology; Prognosis; Pulmonary/Respiratory; Retrospective Studies; Survivin; TNF-alpha; Tumor Necrosis Factor-alpha - blood; Tumors; Tumors of the respiratory system and mediastinum; Nonsmall cell lung cancer; Survivin; TNF-alpha; Apoptosis; Lung disease; Respiratory disease; Lung cancer; Biological marker; Malignant tumor; Cancerology; Tumor necrosis factor; Bronchus disease; Serum; Cell; Cancer; Pneumology
• ISSN: 0169-5002; 1872-8332
• DOI: 10.1016/j.lungcan.2007.08.005

Summary Context This study was conducted to investigate the prognostic role and the effects of chemotherapy on serum apoptosis biomarkers consisting of survivin and tumor necrosis factor alpha (TNF-alpha) in patients with advanced stage nonsmall cell lung cancer (NSCLC). Materials and methods Fifty-seven patients with newly diagnosed NSCLC were enrolled into study. Performance status was 0 or 1 in 47 patients and 2 in 10 patients. Thirty-two of them were no or less than 10% weight loss. Patients were treated with platinum-based chemotherapy. Serum levels of TNF-alpha and survivin were determined by enzyme-linked immunosorbent assay (ELISA) technique. Results While serum survivin levels in patients were not significantly different from controls ( p = 0.321), serum TNF-alpha levels in patients were found significantly higher than in controls ( p = 0.029). We found that serum TNF-alpha levels were increased ( p < 0.001), whereas serum levels of survivin ( p = 0.025) were decreased by the chemotherapy effects. The changes of the TNF-alpha and survivin serum levels due to chemotherapy effect showed a significant negative correlation ( r = −0.36 p = 0.007). The increase of serum TNF-alpha levels was independent from chemotherapy response; however, the reduction of serum survivin levels was found only significant in the chemoresponsive group ( p = 0.039). While older age, weight loss and performance status yielded prognostic value, neither TNF-alpha nor survivin levels proved to be significant for survival. Conclusion Our findings suggest that the reduction in the serum survivin levels of advanced NSCLC patients after chemotherapy can be used as a predictor of response to the chemotherapy but not that of survival.