White blood cells and platelet profiles of diabetic patients at University of Gondar specialized referral hospital: A comparative cross‐sectional study

• Published in: Journal of clinical laboratory analysis Vol. 35; no. 6; pp. e23808 - n/a
• Main Authors: Adane, Tiruneh, Asrie, Fikir, Getaneh, Zegeye, Getawa, Solomon
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01-06-2021; John Wiley and Sons Inc
• Subjects: Blood & organ donations; Blood platelets; Blood pressure; Chronic illnesses; Cross-sectional studies; Cytokines; Diabetes; Diabetes mellitus; Ethics; Ethiopia; Health care; Hematology; Hospitals; Hypertension; Inflammation; Inflammatory diseases; Insulin; Kidney diseases; Laboratories; Leukocytes (neutrophilic); Lymphocytes; Metabolic syndrome; MPV; Overweight; Oxidative stress; platelet indices; Platelets; Smoking; Sociodemographics; Statistical analysis; WBC indices; Ethiopia; MPV; diabetes mellitus; WBC indices; Ethiopia; platelet indices
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.23808

Background
Altered level of many hematological parameters such as white blood cells (WBC) and platelet function has been observed in diabetes mellitus (DM) patients. Therefore, this study aimed to determine the WBC and platelet profiles and their association with anthropometric measurement and blood pressure in DM patients and healthy controls.
Method
A comparative cross‐sectional study was conducted on a total of 246 participants at the University of Gondar Specialized Referral Hospital. Venous blood with K2 EDTA anticoagulant was drawn and analyzed by using Sysmex KX21N hematology analyzers for WBC and platelet parameters. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 20. Results were presented as frequency and mean ± standard deviation (SD). The independent sample t test was used to compare quantitative variables between DM and control groups. The bivariate (spearman's rank) correlation was used to analyze continuous variables. A p‐value ˂ 0.05 was considered as statistically significant.
Results
The mean platelet count was significantly higher among diabetics (252.77 ± 77.7) compared to non‐diabetic controls (208.22 ± 68), p < 0.001. Similarly, the total WBC count was higher among DM patients (6.95 ± 2.23) than in the controls (6.15 ± 1.95), p = 0.04. A significant negative correlation was also found between neutrophil and duration of illness in DM patients. Besides, there is a significant positive correlation between WBC and lymphocyte number with systolic blood pressure (SBP) in DM patients.
Conclusion
Platelet and WBC count were significantly higher in DM patients than in the controls. Therefore, routine screening and profile checking of those abnormal indices is recommended to minimize DM‐related complications.
The mean platelet count was significantly higher among diabetics (252.77 ± 77.7) compared to non‐diabetic controls (208.22 ± 68), p < 0.001. Similarly, the total WBC count was higher among DM patients (6.95 ± 2.23) than in the controls (6.15 ± 1.95), p = 0.04. A significant negative correlation was also found between neutrophil and duration of illness in DM patients. Besides, there is a significant positive correlation between WBC and lymphocyte number with systolic blood pressure (SBP) in DM patients. Platelet and WBC count were significantly higher in DM patients than in the controls. Therefore, routine screening and profile checking of those indices is recommended to minimize DM‐related complications.
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