Electrical Stimulation of Anal Sphincter or Pudendal Nerve Improves Anal Sphincter Pressure

• Published in: Diseases of the colon & rectum Vol. 55; no. 12; pp. 1284 - 1294
• Main Authors: Damaser, Margot S, Salcedo, Levilester, Wang, Guangjian, Zaszczurynski, Paul, Cruz, Michelle A, Butler, Robert S, Jiang, Hai-Hong, Zutshi, Massarat
• Format: Journal Article
• Language: English
• Published: Hagerstown, MDc The ASCRS 01-12-2012; Lippincott Williams & Wilkins
• Subjects: Anal Canal - innervation; Animals; Biological and medical sciences; Electric Stimulation - methods; Fecal Incontinence - physiopathology; Fecal Incontinence - prevention & control; Female; Gastroenterology. Liver. Pancreas. Abdomen; Medical sciences; Pressure; Pudendal Nerve; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome; Urinary Bladder - innervation; Rat; Rodentia; Bladder; Electrical stimulation; Neuromodulation; Pressure; Anal sphincter; Vertebrata; Mammalia; Pudendal nerve; Urinary bladder; Animal; Gastroenterology
• ISSN: 0012-3706; 1530-0358
• DOI: 10.1097/DCR.0b013e31826ae2f8

OBJECTIVE:Stimulation of the pudendal nerve or the anal sphincter could provide therapeutic options for fecal incontinence with little involvement of other organs. The goal of this project was to assess the effects of pudendal nerve and anal sphincter stimulation on bladder and anal pressures.
DESIGN:Ten virgin female Sprague Dawley rats were randomly allocated to control (n = 2), perianal stimulation (n = 4), and pudendal nerve stimulation (n = 4) groups. A monopolar electrode was hooked to the pudendal nerve or placed on the anal sphincter. Aballoon catheter was inserted into the anus to measure anal pressure, and a catheter was inserted into the bladder via the urethra to measure bladder pressure. Bladder and anal pressures were measured with different electrical stimulation parameters and different timing of electrical stimulation relative to spontaneous anal sphincter contractions.
RESULTS:Increasing stimulation current had the most dramatic effect on both anal and bladder pressures. An immediate increase in anal pressure was observed when stimulating either the anal sphincter or the pudendal nerve at stimulation values of 1 mA or 2 mA. No increase in anal pressure was observed for lower current values. Bladder pressure increased at high current during anal sphincter stimulation, but not as much as during pudendal nerve stimulation. Increased bladder pressure during anal sphincter stimulation was due to contraction of the abdominal muscles.
CONCLUSION:Electrical stimulation caused an increase in anal pressures with bladder involvement only at high current. These initial results suggest that electrical stimulation can increase anal sphincter pressure, enhancing continence control.