Self‐reported word‐finding complaints are associated with cerebrospinal fluid amyloid beta and atrophy in cognitively normal older adults

Introduction Self‐reported word‐finding difficulties are among the most frequent complaints in cognitively normal (CN) older adults. However, the clinical significance is still debated. Methods We selected 239 CN from the Alzheimer's Disease Neuroimaging Initiative database who had completed th...

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Bibliographic Details
Published in:	Alzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 14; no. 1; pp. e12274 - n/a
Main Authors:	Montembeault, Maxime, Stijelja, Stefan, Brambati, Simona M.
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 2022 John Wiley and Sons Inc
Subjects:	Aging Alzheimer's disease Anxiety Atrophy Biomarkers Brain research Cerebrospinal fluid Clinical significance Cognitive & Behavioral Assessment Cognitive ability Complaints Dementia Language Magnetic resonance imaging Memory Older people Questionnaires Self report Sociodemographics subjective cognitive decline subjective complaints Variance analysis word finding language subjective cognitive decline aging word finding Alzheimer's disease subjective complaints
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Summary:	Introduction Self‐reported word‐finding difficulties are among the most frequent complaints in cognitively normal (CN) older adults. However, the clinical significance is still debated. Methods We selected 239 CN from the Alzheimer's Disease Neuroimaging Initiative database who had completed the Everyday Cognition (ECog) questionnaire, as well as a lumbar puncture for amyloid beta (Aβ) and magnetic resonance imaging. Results Word‐finding complaints, with a few other memory items, were significantly more severe compared to all other cognitive complaints. Ecog‐Lang1 (Forgetting names of objects) severity significantly predicted Aβ levels in CN, even when controlling for general cognitive complaint, demographic, and psychological variables. Individuals with high Ecog‐Lang1 complaints showed atrophy in the left fusiform gyrus and the left rolandic operculum compared to CN with low complaints. Discussion Overall, our results support the fact that word‐finding complaints should be taken seriously. They have the potential to identify CN at risk of AD and support the need to include other cognitive domains in the investigation of subjective cognitive decline.
Bibliography:	http://adni.loni.usc.edu/wpcontent/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wpcontent/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf
ISSN:	2352-8729 2352-8729
DOI:	10.1002/dad2.12274